Multilayered regulations of RIG-I in the anti-viral signaling pathway
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- Title
- Multilayered regulations of RIG-I in the anti-viral signaling pathway
- Authors
- Nari Kim; Hesung Now; Nguyen Thi Hong Nhung; Yoo, JY
- Date Issued
- 2016-09
- Publisher
- Seoul : Microbiological Society Of Korea
- Abstract
- RIG-I is a cytosolic receptor recognizing virus-specific RNA structures and initiates an antiviral signaling that induces the production of interferons and proinflammatory cytokines.
Because inappropriate RIG-I signaling affects either viral clearance or immune toxicity, multiple regulations of RIG-I have been investigated since its discovery as the viral RNA detector. In this review, we describe the recent progress in research on the regulation of RIG-I activity or abundance.
Specifically, we focus on the mechanism that modulates RIGI- dependent antiviral response through post-translational modifications of or protein-protein interactions with RIG-I.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/37448
- DOI
- 10.1007/S12275-016-6322-2
- ISSN
- 1225-8873
- Article Type
- Article
- Citation
- JOURNAL OF MICROBIOLOGY, vol. 54, no. 9, page. 583 - 587, 2016-09
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