Genome-wide identification of haploinsufficiency in fission yeast
SCIE
SCOPUS
KCI
- Title
- Genome-wide identification of haploinsufficiency in fission yeast
- Authors
- Baek, ST; Han, S; Nam, M; Kim, YD; Kim, L; Lee, HJ; Heo, KS; Lee, H; Lee, M; Park, SK; Maeng, PJ; Park, Y; Lee, S; Kim, DU; Kim, D; Hoe, KL
- Date Issued
- 2008-06
- Publisher
- KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
- Abstract
- Abnormal phenotypes resulting from haploinsufficiency (HI) are due to the loss of one allele. Recent studies in budding yeast have shown that HI originates from insufficient protein levels or from a stoichiometric imbalance between subunits of protein complexes. In humans, however, HI often involves transcription factors. Therefore, the species differences in HI and the molecular mechanisms of species-specific HI remain under investigation. In this study, HI in fission yeast was systematically surveyed. HI in fission yeast affected genes related to signaling and to basic cellular processes, as observed in budding yeast. These results suggest that there are species differences in HI and that the HI that occurs in fission yeast is intermediate to HI in budding yeast and humans.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/37065
- ISSN
- 1017-7825
- Article Type
- Article
- Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, vol. 18, no. 6, page. 1059 - 1063, 2008-06
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.