Non-contact acoustic radiation force impulse microscopy via photoacoustic detection for probing breast cancer cell mechanics
SCIE
SCOPUS
- Title
- Non-contact acoustic radiation force impulse microscopy via photoacoustic detection for probing breast cancer cell mechanics
- Authors
- Hwang, JY; Kang, BJ; Lee, C; Kim, HH; Park, J; Zhou, QF; Shung, KK
- Date Issued
- 2015-01-01
- Publisher
- OPTICAL SOC AMER
- Abstract
- We demonstrate a novel non-contact method: acoustic radiation force impulse microscopy via photoacoustic detection (PA-ARFI), capable of probing cell mechanics. A 30 MHz lithium niobate ultrasound transducer is utilized for both detection of phatoacoustic signals and generation of acoustic radiation force. To track cell membrane displacements by acoustic radiation force, functionalized single-walled carbon nanotubes are attached to cell membrane. Using the developed microscopy evaluated with agar phantoms, the mechanics of highly- and weakly-metastatic breast cancer cells are quantified. These results clearly show that the PA-ARFI microscopy may serve as a novel tool to probe mechanics of single breast cancer cells. (C) 2014 Optical Society of America
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/36631
- DOI
- 10.1364/BOE.6.000011
- ISSN
- 2156-7085
- Article Type
- Article
- Citation
- Biomedical Optics Express, vol. 6, no. 1, page. 11 - 22, 2015-01-01
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