Nano Chocolate Waffle for near-IR Responsive Drug Releasing System
SCIE
SCOPUS
- Title
- Nano Chocolate Waffle for near-IR Responsive Drug Releasing System
- Authors
- Lee, J; Park, H; Kim, WJ
- Date Issued
- 2015-10-21
- Publisher
- WILEY-V C H VERLAG GMBH
- Abstract
- A majority of the photo-responsive drug-delivery systems that are currently being studied require a complicated synthesis method. Here, we prepare a near-infrared responsive, photothermally controllable, drug-delivery carrier by a simple mixing and extraction process without the incorporation of toxic chemicals. A blend of doxorubicin (DOX), an anticancer drug, and a phase-change material (PCM) are loaded onto the mesoporous structure of silica-coated graphene oxide (GO@MS) to form a waffle-like structure, which is confirmed by various physicochemical analyses. The cytotoxicity of DOX/PCM-loaded GO@MS (DOX/PCM-GO@MS) against HeLa cells is 50 times higher than that of free DOX, and this improved activity can be attributed to the photothermal effectiveness of GO@MS. Additionally, the cytotoxicity and uptake mechanism of the PCM-based material are analyzed by flow cytometry. Taken together, our results suggest an enormous potential for spatio-temporal control in photothermally responsive drug-delivery systems.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/36302
- DOI
- 10.1002/SMLL.201403228
- ISSN
- 1613-6810
- Article Type
- Article
- Citation
- SMALL, vol. 11, no. 39, page. 5315 - 5323, 2015-10-21
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- There are no files associated with this item.
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