Mesenchymal Stem Cells Aggregate and Deliver Gold Nanoparticles to Tumors for Photothermal Therapy
SCIE
SCOPUS
- Title
- Mesenchymal Stem Cells Aggregate and Deliver Gold Nanoparticles to Tumors for Photothermal Therapy
- Authors
- Kang, S; Bhang, SH; Hwang, S; Yoon, JK; Song, J; Jang, HK; Kim, S; Kim, BS
- Date Issued
- 2015-10
- Publisher
- AMER CHEMICAL SOC
- Abstract
- Gold nanoparticles (AuNPs) have been extensively studied for photothermal cancer therapy because AuNPs can generate heat upon near-infrared irradiation. However, improving their tumor-targeting efficiency and optimizing the nanoparticle size for maximizing the photothermal effect remain challenging. We demonstrate that mesenchymal stem cells (MSCs) can aggregate pH-sensitive gold nanoparticles (PSAuNPs) in mildly acidic endosomes, target tumors, and be used for photothermal therapy. These aggregated structures had a higher cellular retention in comparison to pH-insensitive, control AuNPs (cAuNPs), which is important for the cell-based delivery process. PSAuNP-laden MSCs (MSC-PSAuNPs) injected intravenously to tumor-bearing mice show a 37-fold higher tumor-targeting efficiency (5.6% of the injected dose) and 8.3 degrees C higher heat generation compared to injections of cAuNPs after irradiation, which results in a significantly enhanced anticancer effect.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/36301
- DOI
- 10.1021/ACSNANO.5B02207
- ISSN
- 1936-0851
- Article Type
- Article
- Citation
- ACS NANO, vol. 9, no. 10, page. 9678 - 9690, 2015-10
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- There are no files associated with this item.
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