Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer
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- Title
- Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer
- Authors
- Lee, JH; You, S; Hyeon, DY; Kang, B; Kim, H; Park, KM; Han, B; Hwang, D; Kim, S
- Date Issued
- 2015-03-29
- Publisher
- OXFORD UNIV PRESS
- Abstract
- Mammalian cells have cytoplasmic and mitochondrial aminoacyl-tRNA synthetases (ARSs) that catalyze aminoacylation of tRNAs during protein synthesis. Despite their housekeeping functions in protein synthesis, recently, ARSs and ARS-interacting multifunctional proteins (AIMPs) have been shown to play important roles in disease pathogenesis through their interactions with disease-related molecules. However, there are lacks of data resources and analytical tools that can be used to examine disease associations of ARS/AIMPs. Here, we developed an Integrated Database for ARSs (IDA), a resource database including cancer genomic/proteomic and interaction data of ARS/AIMPs. IDA includes mRNA expression, somatic mutation, copy number variation and phosphorylation data of ARS/AIMPs and their interacting proteins in various cancers. IDA further includes an array of analytical tools for exploration of disease association of ARS/AIMPs, identification of disease-associated ARS/AIMP interactors and reconstruction of ARS-dependent disease-perturbed network models. Therefore, IDA provides both comprehensive data resources and analytical tools for understanding potential roles of ARS/AIMPs in cancers.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/36255
- DOI
- 10.1093/DATABASE/BAV022
- ISSN
- 1758-0463
- Article Type
- Article
- Citation
- DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2015-03-29
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- There are no files associated with this item.
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