Nitric oxide-releasing polymer incorporated ointment for cutaneous wound healing
SCIE
SCOPUS
- Title
- Nitric oxide-releasing polymer incorporated ointment for cutaneous wound healing
- Authors
- Youngnam Kang; Jihoon Kim; Yeong Mi Lee; Sooseok Im; Hansoo Park; Kim, WJ
- Date Issued
- 2015-12-28
- Publisher
- ELSEVIER SCIENCE BV
- Abstract
- This work demonstrates the development of nitric oxide-releasing ointment and its potential on efficient wound healing. Nitric oxide-releasing polymer was successfully synthesized, which is composed of biocompatible Pluronic F127, branched polyethylenimine and 1-substituted diazen-1-ium-1,2-diolates. The synthesized nitric oxide-releasing polymer was incorporated into the PEG-based ointment which not only facilitated nitric oxide release in a slow manner, but also served as a moisturizer to enhance the wound healing. As compared to control groups, the nitric oxide-releasing ointment showed the accelerated wound closure with enhanced re-epithelialization, collagen deposition, and blood vessel formation in vivo. Therefore, this nitric oxide-based ointment presents the promising potential for the efficient strategy to heal the cutaneous wound. (C) 2015 Elsevier B.V. All rights reserved.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/36072
- DOI
- 10.1016/J.JCONREL.2015.08.057
- ISSN
- 0168-3659
- Article Type
- Article
- Citation
- JOURNAL OF CONTROLLED RELEASE, vol. 220, page. 624 - 630, 2015-12-28
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