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In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy SCIE SCOPUS

Title
In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy
Authors
Jang, WHShim, SWang, TYoon, YJang, WSMyung, JKPark, SKim, KH
Date Issued
2016-01-12
Publisher
Nature Publishing Group
Abstract
Ionizing radiation (IR) injury is tissue damage caused by high energy electromagnetic waves such as X-ray and gamma ray. Diagnosis and treatment of IR injury are difficult due to its characteristics of clinically latent post-irradiation periods and the following successive and unpredictable inflammatory bursts. Skin is one of the many sensitive organs to IR and bears local injury upon exposure. Early-stage diagnosis of IR skin injury is essential in order to maximize treatment efficiency and to prevent the aggravation of IR injury. In this study, early-stage changes of the IR injured skin at the cellular level were characterized in an in vivo mouse model by two-photon microscopy (TPM). Various IR doses were applied to the mouse hind limbs and the injured skin regions were imaged daily for 6 days after IR irradiation. Changes in the morphology and distribution of the epidermal cells and damage of the sebaceous glands were observed before clinical symptoms. These results showed that TPM is sensitive to early-stage changes of IR skin injury and may be useful for its diagnosis.
URI
https://oasis.postech.ac.kr/handle/2014.oak/35707
DOI
10.1038/SREP19216
ISSN
2045-2322
Article Type
Article
Citation
Scientific Reports, vol. 6, 2016-01-12
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김기현KIM, KI HEAN
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