Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist
SCIE
SCOPUS
- Title
- Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist
- Authors
- Sugawara, R; Lee, EJ; Jang, MS; Jeun, EJ; Hong, CP; Kim, JH; Park, A; Yun, CH; Hong, SW; KIM, YOU ME; Seoh, JY; Jung, Y; Surh, CD; Miyasaka, M; Yang, BG; Jang, MH
- Date Issued
- 2016-04-04
- Publisher
- Journal of Experimental Medicine
- Abstract
- Eosinophils play proinflammatory roles in helminth infections and allergic diseases. Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. In this study, we found that small intestinal eosinophils down-regulate Th17 cells. Th17 cells in the small intestine were markedly increased in the Delta dblGATA-1 mice lacking eosinophils, and an inverse correlation was observed between the number of eosinophils and that of Th17 cells in the small intestine of wild-type mice. In addition, small intestinal eosinophils suppressed the in vitro differentiation of Th17 cells, as well as IL-17 production by small intestinal CD4(+) T cells. Unlike other small intestinal immune cells or circulating eosinophils, we found that small intestinal eosinophils have a unique ability to constitutively secrete high levels of IL-1 receptor antagonist (IL-1Ra), a natural inhibitor of IL-1 beta. Moreover, small intestinal eosinophils isolated from IL-1Ra-deficient mice failed to suppress Th17 cells. Collectively, our results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/29968
- DOI
- 10.1084/JEM.20141388
- ISSN
- 0022-1007
- Article Type
- Article
- Citation
- Journal of Experimental Medicine, vol. 213, no. 4, page. 555 - 567, 2016-04-04
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