Angiogenic activity of human CC chemokine CCL15 in vitro and in vivo
SCIE
SCOPUS
- Title
- Angiogenic activity of human CC chemokine CCL15 in vitro and in vivo
- Authors
- Hwang, JS; Kim, CW; Son, KN; Han, KY; Lee, KH; Hynda K Kleinman; Koe, J; Na, DS; Byoung S Kwon; Gho, YS; Kim, J
- Date Issued
- 2004-07-16
- Publisher
- ELSEVIER SCIENCE BV
- Abstract
- CCL15 is a novel human CC chemokine and exerts its biological activities on immune cells through CCR1 and CCR3. Because a number of chemokines induce angiogenesis and endothelial cells express CCR1 and CCR3, we investigated the angiogenic activity of CCL15. Both CCL15(1-92) and N-terminal truncated CCL15(25-92) stimulate the chemotactic endothelial cell migration and differentiation, but CCL15(25-92) is at least 100-fold more potent than CCL15(1-92). Treatment with pertussis toxin (PTX), with anti-CCR1, or with anti-CCR3 antibody inhibits the CCL15(25-92)-induced endothelial cell migration. CCL15(25-92) also stimulates sprouting of vessels from aortic rings and mediates angiogenesis in the chick chorioallantoic membrane assay. Our findings demonstrate that CCL15(25-92) has in vitro and in vivo angiogenic activity, and suggest roles of the chemokine in angiogenesis. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
- Keywords
- chemokine; CCL15; endothelial cells; angiogenesis; CCR1; CCR3; INTERCELLULAR-ADHESION MOLECULE-1; ENDOTHELIAL GROWTH-FACTOR; HEMOFILTRATE CC-CHEMOKINE-1; BIOLOGICAL-ACTIVITY; LEUKOTACTIN-1; CELLS; EXPRESSION; RECEPTORS; NEUTROPHILS; AGONIST
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/29626
- DOI
- 10.1016/j.febslet.2004.06.023
- ISSN
- 0014-5793
- Article Type
- Article
- Citation
- FEBS LETTERS, vol. 570, no. 1-3, page. 47 - 51, 2004-07-16
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