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Enzymatic resolution of racemic ibuprofen esters: Effects of organic cosolvents and temperature SCIE SCOPUS
- Title
- Enzymatic resolution of racemic ibuprofen esters: Effects of organic cosolvents and temperature
- Date Issued
- 1995-01
- Publisher
- SOC FERMENTATION BIOENGINEERING, JAPA
- Abstract
- The effects of organic additives on enzymatic hydrolysis of racemic ibuprofen methyl ester were investigated using Candida cylindracea lipase. Several polar solvents such as N,N-dimethylformamide, formaldehyde, and formamide were found to enhance the enantioselectivity of the enzyme. The effects of temperature on enzyme selectivity were also examined.
- Keywords
- ibuprofen; enzymatic resolution; organic solvent; enantioselectivity; lipase; Candida cylindracea; SOLVENTS
- ISSN
- 0922-338X
- Article Type
- Article
- Citation
- JOURNAL OF FERMENTATION AND BIOENGINEERING, vol. 80, no. 6, page. 613 - 615, 1995-01
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