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Cited 1628 time in webofscience Cited 1705 time in scopus
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COMBINATORIAL PATTERNS OF HISTONE ACETYLATIONS AND METHYLATIONS IN THE HUMAN GENOME SCIE SCOPUS

Title
COMBINATORIAL PATTERNS OF HISTONE ACETYLATIONS AND METHYLATIONS IN THE HUMAN GENOME
Authors
Wang, ZBZang, CZRosenfeld, JASchones, DEBarski, ACuddapah, SCui, KRRoh, TYPeng, WQZhang, MQZhao, KJ
Date Issued
2008-07
Publisher
NATURE PUBLISHING GROUP
Abstract
Histones are characterized by numerous posttranslational modifications that influence gene transcription(1,2). However, because of the lack of global distribution data in higher eukaryotic systems(3), the extent to which gene-specific combinatorial patterns of histone modifications exist remains to be determined. Here, we report the patterns derived from the analysis of 39 histone modifications in human CD4(+) T cells. Our data indicate that a large number of patterns are associated with promoters and enhancers. In particular, we identify a common modification module consisting of 17 modifications detected at 3,286 promoters. These modifications tend to colocalize in the genome and correlate with each other at an individual nucleosome level. Genes associated with this module tend to have higher expression, and addition of more modifications to this module is associated with further increased expression. Our data suggest that these histone modifications may act cooperatively to prepare chromatin for transcriptional activation.
Keywords
CHROMATIN DOMAINS; GENE-EXPRESSION; T-CELLS; TRANSCRIPTION; ENHANCERS; LANGUAGE; COMPLEX; CODE
URI
https://oasis.postech.ac.kr/handle/2014.oak/28991
DOI
10.1038/NG.154
ISSN
1061-4036
Article Type
Article
Citation
NATURE GENETICS, vol. 40, no. 7, page. 897 - 903, 2008-07
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노태영ROH, TAE YOUNG
Dept of Life Sciences
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