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High-resolution profiling of histone methylations in the human genome SCIE SCOPUS

Title
High-resolution profiling of histone methylations in the human genome
Authors
Barski, ACuddapah, SCui, KRRoh, TYSchones, DEWang, ZBWei, GChepelev, IZhao, KJ
Date Issued
2007-05-18
Publisher
CELL PRESS
Abstract
Histone modifications are implicated in influencing gene expression. We have generated high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology. Typical patterns of histone methylations exhibited at promoters, insulators, enhancers, and transcribed regions are identified. The monomethylations of H3K27, H3K9, H4K20, H3K79, and H2BK5 are all linked to gene activation, whereas trimethylations of H3K27, H3K9, and H3K79 are linked to repression. H2A.Z associates with functional regulatory elements, and CTCF marks boundaries of histone methylation domains. Chromosome banding patterns are correlated with unique patterns of histone modifications. Chromosome breakpoints detected in T cell cancers frequently reside in chromatin regions associated with H3K4 methylations. Our data provide new insights into the function of histone methylation and chromatin organization in genome function.
Keywords
EMBRYONIC STEM-CELLS; ACTIVE GENES; T-CELLS; DEVELOPMENTAL REGULATORS; SACCHAROMYCES-CEREVISIAE; MAMMALIAN CHROMATIN; CODING REGIONS; WIDE; H2A.Z; H3
URI
https://oasis.postech.ac.kr/handle/2014.oak/28971
DOI
10.1016/J.CELL.2007.05.009
ISSN
0092-8674
Article Type
Article
Citation
CELL, vol. 129, no. 4, page. 823 - 837, 2007-05-18
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노태영ROH, TAE YOUNG
Dept of Life Sciences
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