COUMARIN-DERIVED CU2+-SELECTIVE FLUORESCENCE SENSOR: SYNTHESIS, MECHANISMS, AND APPLICATIONS IN LIVING CELLS
SCIE
SCOPUS
- Title
- COUMARIN-DERIVED CU2+-SELECTIVE FLUORESCENCE SENSOR: SYNTHESIS, MECHANISMS, AND APPLICATIONS IN LIVING CELLS
- Authors
- Jung, HS; Kwon, PS; Lee, JW; Kim, JI; Hong, CS; Kim, JW; Yan, SH; Lee, JY; Lee, JH; Joo, T; Kim, JS
- Date Issued
- 2009-02-11
- Publisher
- AMER CHEMICAL SOC
- Abstract
- A novel coumarin-based fluorogenic probe bearing the 2-picolyl unit (1) was developed as a fluorescent chemosensor with high selectivity and suitable affinity in biological systems toward Cu2+ over other cations tested. The fluorescence on-off mechanism was studied by femtosecond time-resolved fluorescence (TRF) upconversion technique and ab initio calculations. The receptor can be applied to the monitoring of Cu2+ ion in aqueous solution with a pH span 4-10. To confirm the suitability of 1 for biological applications, we also employed it for the fluorescence detection of the changes of intracellular Cu2+ in cultured cells. The results indicate that 1 should be useful for the fluorescence microscopic imaging and the study on the biological functions Of Cu2+..
- Keywords
- FLUORIDE-SELECTIVE FLUORESCENT; HYDROGEN-PEROXIDE; CU-II; COPPER; ION; CHEMOSENSOR; FLUOROIONOPHORE; COMPLEXES; ZINC; FLUOROPHORE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/28962
- DOI
- 10.1021/JA808611D
- ISSN
- 0002-7863
- Article Type
- Article
- Citation
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 131, no. 5, page. 2008 - 2012, 2009-02-11
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