SYNTHETIC SURFACES AS ARTIFICIAL ANTIGEN PRESENTING CELLS IN THE STUDY OF T CELL RECEPTOR TRIGGERING AND IMMUNOLOGICAL SYNAPSE FORMATION
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- Title
- SYNTHETIC SURFACES AS ARTIFICIAL ANTIGEN PRESENTING CELLS IN THE STUDY OF T CELL RECEPTOR TRIGGERING AND IMMUNOLOGICAL SYNAPSE FORMATION
- Authors
- Irvine, DJ; Doh, JS
- Date Issued
- 2007-08
- Publisher
- ACADEMIC PRESS LTD ELSEVIER SCIENCE L
- Abstract
- T cell activation occurs when T cell receptors engage peptide-major histocompatibility complex (pMHC molecules displayed on the surface of antigen presenting cells (APCs). Clustering of TCRs and other receptors in physical patterns at the T-APC interface forms a structure known as an immunological synapse (IS). Studies of the IS are challenging due to the cell-cell contact context of the governing interactions. Model surfaces as synthetic APCs have thus been developed, where the type, quantity, and physical arrangement of ligands displayed to T cells are precisely controlled. These model systems have provided important insights into the structure and function of the IS. (c) 2007 Elsevier Ltd. All rights reserved.
- Keywords
- T cell activation; immunological synapse; supported bilayer; microfabrication; Nanotechnology; SUPPORTED PLANAR MEMBRANES; SUPRAMOLECULAR ACTIVATION CLUSTER; PATTERNED LIPID-BILAYERS; DENDRITIC CELLS; RECOGNITION; ADHESION; LYMPHOCYTES; LIGAND; NAIVE; TCR
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/28471
- DOI
- 10.1016/J.SIMM.2007.
- ISSN
- 1044-5323
- Article Type
- Article
- Citation
- SEMINARS IN IMMUNOLOGY, vol. 19, no. 4, page. 245 - 254, 2007-08
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