Open Access System for Information Sharing

Login Library

 

Article
Cited 38 time in webofscience Cited 0 time in scopus
Metadata Downloads

1,2,3,4,6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor. SCIE SCOPUS

Title
1,2,3,4,6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor.
Authors
Lee, SJLee, HMJie, STLee, SRMar, WGho, YS
Date Issued
2004-05-10
Publisher
ELSEVIER SCI IRELAND LTD
Abstract
Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is the most important angiogenic molecule associated with tumor-induced neovascularization. VEGF exerts its activity through binding to its receptor tyrosine kinase, KDR/Flk-1, expressed on the surface of endothelial cells. From the screening of medicinal plants, we have identified 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) from the roots of Paeonia lactiflora that inhibited the binding of VEGF to KDR/Flk-1. PGG efficiently blocked VEGF-induced human umbilical vein endothelial cell proliferation and the growth of immortalized human microvascular endothelial cells, but did not affect the growth of HT1080 human fibrosarcoma and DU-145 human prostate carcinoma cells. PGG also blocked VEGF-induced capillary-like tube formation of endothelial cell on Matrigel. Our results suggest that PGG could be a candidate for developing anti-angiogenic agent. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
Keywords
1,2,3,4.6-penta-O-galloyl-beta-D-glucose; vascular endothelial growth factor; KDR/Flk-1; angiogenesis; cancer; TUMOR-GROWTH; CANCER-THERAPY; IN-VITRO; ANGIOGENESIS; METASTASIS; VASCULOGENESIS; EXPRESSION; LETHALITY; MITOGEN; FLK-1
URI
https://oasis.postech.ac.kr/handle/2014.oak/28389
DOI
10.1016/J.CANLET.200
ISSN
0304-3835
Article Type
Article
Citation
CANCER LETTERS, vol. 208, no. 1, page. 89 - 94, 2004-05-10
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

고용송GHO, YONG SONG
Dept of Life Sciences
Read more

Views & Downloads

Browse