Water-Soluble Porphyrin-Polyethylene Glycol Conjugates with Enhanced Cellular Uptake for Photodynamic Therapy
SCIE
SCOPUS
- Title
- Water-Soluble Porphyrin-Polyethylene Glycol Conjugates with Enhanced Cellular Uptake for Photodynamic Therapy
- Authors
- Kim, WJ; Kang, MS; Kim, HK; Kim, Y; Chang, TH; Ohulchanskyy, T; Prasad, PN; Lee, KS
- Date Issued
- 2009-12
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Abstract
- Water soluble porphyrins were designed and prepared by Williamson ether synthesis reaction between tetrakis(p-bromomethylphenyl)porphyrin and polyethylene glycol (PEG) for photodynamic therapy. The quantum yields for the generation of singlet oxygen of tetra-polyethylene glycol branched porphyrin shows above 80% in D2O. Luminescence of singlet state oxygen was observed from D2O solution under the single-photon excitation at 514 nm. In vitro test, cellular uptake efficiency has been enhanced by simple modification of molecular structure through changing the number of PEG unit without any support such as polymer-encapsulated inorganic nanoparticles.
- Keywords
- Photodynamic Therapy; Porphyrin Derivatives; Singlet Oxygen Generation; Bio-Imaging; NEUTRON-CAPTURE THERAPY; STAR POLYMERS; TUMOR-MODEL; COMPLEXES; CANCER; OXYGEN; CORE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/27780
- DOI
- 10.1166/JNN.2009.1641
- ISSN
- 1533-4880
- Article Type
- Article
- Citation
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, vol. 9, no. 12, page. 7130 - 7135, 2009-12
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- There are no files associated with this item.
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