Hyaluronic Acid-Gold Nanoparticle/Interferon alpha Complex for Targeted Treatment of Hepatitis C Virus Infection
SCIE
SCOPUS
- Title
- Hyaluronic Acid-Gold Nanoparticle/Interferon alpha Complex for Targeted Treatment of Hepatitis C Virus Infection
- Authors
- Lee, MY; Yang, JA; Jung, HS; Beack, S; Choi, JE; Hur, W; Koo, H; Kim, K; Yoon, SK; Hahn, SK
- Date Issued
- 2012-11
- Publisher
- ACS NANO
- Abstract
- Gold nanoparticles (AuNPs) have been extensively investigated as an emerging delivery-carrier of various biopharmaceuticals. Instead of nonspecific polyethylene glycol (PEG) conjugated interferon alpha (IFN alpha) for the clinical treatment of hepatitis C virus (HCV) Infection, in this work, a target-specific long-acting delivery system of IFN alpha was successfully developed using the hybrid materials of AuNP and hyaluronic add (HA). The HA-AuNP/IFN alpha complex was prepared by chemical binding of thiolated HA and physical binding of IFN alpha to AuNP. According to antiproliferation tests in Daudi cells, the HA-AuNP/IFN alpha complex showed a comparable biological activity to PEG-Intron with a highly enhanced stability in human serum. Even 7 days postinjection, HA-AuNP/IFN alpha complex was target-specifically delivered and remained in the murine liver tissue, whereas IFN alpha and PEG-Intron were not detected in the liver. Accordingly, HA-AuNP/IFN alpha complex significantly enhanced the expression of 2',5'-oligoadenylate synthetase 1 (OAS1) for innate immune responses to viral infection In the liver tissue, which was much higher than those by IFN alpha, PEG-Intron, and AuNP/IFN alpha complex. Taken together, the target specific HA-AuNP/IFN alpha complex was thought to be successfully applied to the systemic treatment of HCV infection.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/27471
- DOI
- 10.1021/NN302538Y
- ISSN
- 1936-0851
- Article Type
- Article
- Citation
- ACS NANO, vol. 6, no. 11, page. 9522 - 9531, 2012-11
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