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Cited 14 time in webofscience Cited 15 time in scopus
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PDMS bonding to a bio-friendly photoresist via self-polymerized poly(dopamine) adhesive for complex protein micropatterning inside microfluidic channels SCIE SCOPUS

Title
PDMS bonding to a bio-friendly photoresist via self-polymerized poly(dopamine) adhesive for complex protein micropatterning inside microfluidic channels
Authors
Miju KimKwang Hoon SongDoh, J
Date Issued
2013-12-01
Publisher
ELSEVIER
Abstract
Protein micropatterned surfaces integrated with microfluidics are useful in numerous bioanalytical and biological applications. In this study, we demonstrated the fabrication of complex protein micropatterned surfaces within poly(dimethylsiloxane) (PDMS) microfluidic channels by attaching the PDMS channels to bio-friendly photoresist films and subsequently performing microscope projection photolithography (MPP). A muscle-inspired poly(dopamine) (PDA) coating was employed to mediate the bonding between the PDMS and the bio-friendly photoresist poly(2,2-dimethoxy nitrobenzyl methacrylate-r-methyl methacrylate-r-poly(ethylene glycol) methacrylate) (PDMP). By adjusting the clip-coating time for the PDA coating, we could successfully introduce sufficient amounts of functional groups on the PDMP surfaces to mediate strong bonding between the PDMS channels and the PDA-coated PDMP thin films with minimal alteration of the surface properties of the POMP thin films that are critical for protein micropatterning. Using this novel bonding strategy, we successfully fabricated multiple protein micropatterns and gradient micropatterns of proteins within microfluidic channels. The technique developed in this study will be useful for the fabrication of complex biochips for multiplex bioassays and fundamental cell biological studies. (C) 2013 Elsevier B.V. All rights reserved.
URI
https://oasis.postech.ac.kr/handle/2014.oak/27383
DOI
10.1016/J.COLSURFB.2013.07.021
ISSN
0927-7765
Article Type
Article
Citation
COLLOIDS AND SURFACES B-BIOINTERFACES, vol. 112, page. 134 - 138, 2013-12-01
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도준상DOH, JUN SANG
Dept of Mechanical Enginrg
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