NF kappa B and STAT3 synergistically activate the expression of FAT10, a gene counteracting the tumor suppressor p53
SCIE
SCOPUS
- Title
- NF kappa B and STAT3 synergistically activate the expression of FAT10, a gene counteracting the tumor suppressor p53
- Authors
- Yongwook Choi; KIM, JONG KYOUNG; Yoo, JY
- Date Issued
- 2014-05
- Publisher
- Elsevier BV
- Abstract
- Chronic inflammation is one of the main causes of cancer, yet the molecular mechanism underlying this effect is not fully understood. In this study, we identified FAT10 as a potential target gene of STAT3, the expression of which is synergistically induced by NF kappa B co-stimulation. STAT3 binding stabilizes NF kappa B on the FAT10 promoter and leads to maximum induction of FAT10 gene expression. Increased FAT10 represses the transcriptional activity of the tumor suppressor p53, a protein that accelerates the protein degradation of FAT10. This FAT10-p53 double-negative regulation is critical in the control of tumorigenesis, as overexpressed FAT10 facilitates the tumor progression in the solid tumor model. In conclusion, transcriptional synergy between STAT3 and NF kappa B functions to put weight on FAT10 in the mutually inhibitory FAT10-p53 regulatory loop and thus favors tumorigenesis under inflammatory conditions. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/27292
- DOI
- 10.1016/J.MOLONC.2014.01.007
- ISSN
- 1574-7891
- Article Type
- Article
- Citation
- Molecular Oncology, vol. 8, no. 3, page. 642 - 655, 2014-05
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