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Cited 16 time in webofscience Cited 17 time in scopus
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The relationship between serial [(18)F]PBR06 PET imaging of microglial activation and motor function following stroke in mice SCIE SCOPUS

Title
The relationship between serial [(18)F]PBR06 PET imaging of microglial activation and motor function following stroke in mice
Authors
Lartey, FMAhn, GOAli, RRosenblum, SMiao, ZArksey, NShen, BColomer, MVRafat, MLiu, HGAlejre-Alcazar, MAChen, JWPalmer, TChin, FTGuzman, RLoo, BWGraves, E
Date Issued
2014-12
Publisher
SpringerLink
Abstract
Using [(18) F]PBR06 positron emission tomography (PET) to characterize the time course of stroke-associated neuroinflammation (SAN) in mice, to evaluate whether brain microglia influences motor function after stroke, and to demonstrate the use of [(18) F]PBR06 PET as a therapeutic assessment tool. Stroke was induced by transient middle cerebral artery occlusion (MCAO) in Balb/c mice (control, stroke, and stroke with poststroke minocycline treatment). [18 F]PBR06 PET/CT imaging, rotarod tests, and immunohistochemistry (IHC) were performed 3, 11, and 22 days poststroke induction (PSI). The stroke group exhibited significantly increased microglial activation, and impaired motor function. Peak microglial activation was 11 days PSI. There was a strong association between microglial activation, motor function, and microglial protein expression on IHC. Minocycline significantly reduced microglial activation and improved motor function by day 22 PSI. [18 F]PBR06 PET imaging noninvasively characterizes the time course of SAN, and shows increased microglial activation is associated with decreased motor function.
URI
https://oasis.postech.ac.kr/handle/2014.oak/27263
DOI
10.1007/S11307-014-0745-0
ISSN
1536-1632
Article Type
Article
Citation
MOLECULAR IMAGING AND BIOLOGY, vol. 16, no. 6, page. 821 - 829, 2014-12
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안지완AHN, G ONE
Div of Integrative Biosci & Biotech
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