Dynamic Kinetic Resolution of Diarylmethanols with an Activated Lipoprotein Lipase
SCIE
SCOPUS
- Title
- Dynamic Kinetic Resolution of Diarylmethanols with an Activated Lipoprotein Lipase
- Authors
- Jusuk Lee; Yeonock Oh; Yoon Kyung Choi; Eunjeong Choi; Kyungwoo; Park, J; KIM, MAHN JOO
- Date Issued
- 2015-02
- Publisher
- AMER CHEMICAL SOC
- Abstract
- We explored the kinetic resolution of 31 different diarylmethanols with an activated lipoprotein lipase (LPL-D1) which was about 3000-fold more active than its native counterpart in organic solvent. Most of the substrates tested were accepted by LPL-D1 with good to high enantioselectivity in the kinetic resolution. Next, we explored the dynamic kinetic resolutions (DKRs) of these substrates (24 out of 31) using LPL-D1 and a ruthenium-based racemization catalyst in combination, which provided satisfactory yields (71-96%) and high enantiopurities (90-99% cc). As an illustrative example for the synthetic applications of the DKR procedure, we synthesized L-cloperastine, an antitussive drug, from phenyl-(p-trimethylsilylphenyl)methanol via DKR.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/27249
- DOI
- 10.1021/CS501629M
- ISSN
- 2155-5435
- Article Type
- Article
- Citation
- ACS CATALYSIS, vol. 5, no. 2, page. 683 - 689, 2015-02
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- There are no files associated with this item.
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