Supramolecular Hydrogels for Long-Term Bioengineered Stem Cell Therapy
SCIE
SCOPUS
- Title
- Supramolecular Hydrogels for Long-Term Bioengineered Stem Cell Therapy
- Authors
- Yeom, J; Kim, SJ; Jung, H; Namkoong, H; Yang, J; Hwang, BW; Oh, K; KIM, KIMOON; Sung, YC; Hahn, SK
- Date Issued
- 2015-01-28
- Publisher
- WILEY
- Abstract
- Synthetic hydrogels have been extensively investigated as artificial extracellular matrices (ECMs) for tissue engineering in vitro and in vivo. Crucial challenges for such hydrogels are sustaining long-term cytocompatible encapsulation and providing appropriate cues at the right place and time for spatio-temporal control of the cells. Here, in situ supramolecularly assembled and modularly modified hydrogels for long-term engineered mesenchymal stem cell (eMSC) therapy are reported using cucurbit[6]uril-conjugated hyaluronic acid (CB[6]-HA), diaminohexane conjugated HA (DAH-HA), and drug-conjugated CB[6] (drug-CB[6]). The eMSCs producing enhanced green fluorescence protein (EGFP) remain alive and emit the fluorescence within CB[6]/DAH-HA hydrogels in mice for more than 60 d. Furthermore, the long-term expression of mutant interleukin-12 (IL-12M) by eMSCs within the supramolecular hydrogels results in effective inhibition of tumor growth with a significantly enhanced survival rate. Taken together, these findings confirm the feasibility of supramolecular HA hydrogels as 3D artificial ECMs for cell therapies and tissue engineering applications.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/27235
- DOI
- 10.1002/ADHM.201400304
- ISSN
- 2192-2640
- Article Type
- Article
- Citation
- ADVANCED HEALTHCARE MATERIALS, vol. 4, no. 2, page. 237 - 244, 2015-01-28
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.