Synthesis and screening of small-molecule alpha-helix mimetic libraries targeting protein-protein interactions
SCIE
SCOPUS
- Title
- Synthesis and screening of small-molecule alpha-helix mimetic libraries targeting protein-protein interactions
- Authors
- Moon, H; Lim, HS
- Date Issued
- 2015-02
- Publisher
- ELSEVIER SCI LTD
- Abstract
- alpha-Helices are the most common protein secondary structure and play a key role in mediating many protein-protein interactions (PPIs) by serving as recognition motifs. Given that aberrant alpha-helix-mediated PPIs are linked to various disease states, targeting such interactions with small-molecules represents an attractive strategy to develop therapeutic candidates for the related diseases. Over the last decade, significant efforts have been directed toward developing alpha-helix mimetic small-molecules that can modulate alpha-helix-mediated PPIs. In this review, we will highlight recent advances in the development of non-peptidic, small-molecule alpha-helix mimetics with a focus on library synthesis and screening methods to efficiently discover small-molecule alpha-helix mimetics.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/27097
- DOI
- 10.1016/J.CBPA.2014.10.023
- ISSN
- 1367-5931
- Article Type
- Article
- Citation
- CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 24, page. 38 - 47, 2015-02
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- There are no files associated with this item.
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