Synthesis, Physicochemical Characteristics, and Biocompatibility of Self-Assemble Polymers Bearing Guanine, Cytosine, Uracil, and Thymine Moieties
SCIE
SCOPUS
- Title
- Synthesis, Physicochemical Characteristics, and Biocompatibility of Self-Assemble Polymers Bearing Guanine, Cytosine, Uracil, and Thymine Moieties
- Authors
- Kim, JC; Kim, M; Jung, J; Lee, J; Ree, BJ; Kim, H; Kim, IJ; Kim, JR; Ree, M
- Date Issued
- 2015-05-01
- Publisher
- WILEY-BLACKWELL
- Abstract
- We synthesized chemically well-defined brush (i.e., comb-like) polymers bearing guanine, cytosine, uracil, or thymine moieties at the bristle ends. The polymers were stable up to 220 degrees C and were readily solution-processable, yielding high-quality films. Interestingly, the brush polymers favorably self-assembled to form molecular multibilayer structures stabilized by hydrogen bonding interactions among the nucleobase moieties at the bristle ends, which provided nucleobase-rich surfaces. The multibilayer-structured polymer films showed high water affinity. They also displayed selective protein adsorption, suppressed bacterial adherence, facilitated cell adhesion, and exhibited good biocompatibility in mice. The brush polymer DNA-mimicking comb-like polymers are suitable as biomaterials and in protein separation applications. (c) 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 1151-1160
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/27046
- DOI
- 10.1002/POLA.27546
- ISSN
- 0887-624X
- Article Type
- Article
- Citation
- JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, vol. 53, no. 9, page. 1151 - 1160, 2015-05-01
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