Outer Membrane Vesicles Derived from Escherichia coli Induce Systemic Inflammatory Response Syndrome
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SCOPUS
- Title
- Outer Membrane Vesicles Derived from Escherichia coli Induce Systemic Inflammatory Response Syndrome
- Authors
- Park, KS; Choi, KH; Kim, YS; Hong, BS; Kim, OY; Kim, JH; Yoon, CM; Koh, GY; Kim, YK; Gho, YS
- Date Issued
- 2010-06-28
- Publisher
- PUBLIC LIBRARY SCIENCE
- Abstract
- Sepsis, characterized by a systemic inflammatory state that is usually related to Gram-negative bacterial infection, is a leading cause of death worldwide. Although the annual incidence of sepsis is still rising, the exact cause of Gram-negative bacteria-associated sepsis is not clear. Outer membrane vesicles (OMVs), constitutively secreted from Gram-negative bacteria, are nano-sized spherical bilayered proteolipids. Using a mouse model, we showed that intraperitoneal injection of OMVs derived from intestinal Escherichia coli induced lethality. Furthermore, OMVs induced host responses which resemble a clinically relevant condition like sepsis that was characterized by piloerection, eye exudates, hypothermia, tachypnea, leukopenia, disseminated intravascular coagulation, dysfunction of the lungs, hypotension, and systemic induction of tumor necrosis factor-alpha and interleukin-6. Our study revealed a previously unidentified causative microbial signal in the pathogenesis of sepsis, suggesting OMVs as a new therapeutic target to prevent and/or treat severe sepsis caused by Gram-negative bacterial infection.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/25671
- DOI
- 10.1371/JOURNAL.PONE.0011334
- ISSN
- 1932-6203
- Article Type
- Article
- Citation
- PLOS ONE, vol. 5, no. 6, page. E11334, 2010-06-28
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