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Chemoenzymatic Synthesis of Rivastigmine via Dynamic Kinetic Resolution as a Key Step SCIE SCOPUS
- Title
- Chemoenzymatic Synthesis of Rivastigmine via Dynamic Kinetic Resolution as a Key Step
- Date Issued
- 2010-05-07
- Publisher
- AMER CHEMICAL SOC
- Abstract
- A practical and efficient procedure for the synthesis of rivastigmine was developed. This procedure includes dynamic kinetic resolution using a polymer-bound ruthenium complex and a lipase in combination as a key step. Enantiopure (-)-rivastigmine was obtained from commercially available 3'-hydroxyacetophenone via five steps in overall 57% yield.
- Keywords
- SECONDARY ALCOHOLS; RACEMIZATION CATALYSTS; ASYMMETRIC TRANSFORMATIONS; AMBIENT-TEMPERATURE; ALZHEIMERS-DISEASE; ALLYLIC ALCOHOLS; METAL; RUTHENIUM; ENZYMES; COMBINATION
- ISSN
- 0022-3263
- Article Type
- Article
- Citation
- JOURNAL OF ORGANIC CHEMISTRY, vol. 75, no. 9, page. 3105 - 3108, 2010-05-07
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Related Researcher
- 김만주KIM, MAHN JOO
- Dept of Chemistry