hnRNP Q and PTB modulate the circadian oscillation of mouse Rev-erb alpha via IRES-mediated translation
SCIE
SCOPUS
- Title
- hnRNP Q and PTB modulate the circadian oscillation of mouse Rev-erb alpha via IRES-mediated translation
- Authors
- Kim, DY; Woo Kyung Chul; Lee Kyung Ha; Kim Tae Don; KIM, KYONG TAI
- Date Issued
- 2010-11
- Publisher
- OXFORD UNIV PRESS
- Abstract
- The physiological and behavioral circadian rhythms of most creatures are controlled by a harmony of functional relationships between clock genes. In mammals, several core clock genes show rhythmic profiles of their mRNA and protein expression. Among them, Rev-erb alpha functions as a transcriptional repressor, affecting expression patterns of other clock genes. For the continuous and robust oscillation of the molecular clock system, the levels of Rev-erb alpha protein are expected to be tightly regulated with the correct timing. Here, we demonstrate that Rev-erb alpha has an internal ribosomal entry site (IRES) in its 5' untranslated region. Furthermore, we demonstrate that heterogeneous nuclear ribonucleoprotein Q and polypyrimidine tract-binding protein (PTB) modulate the IRES-mediated translation of Rev-erb alpha. We suggest that the rhythmic binding affinity of hnRNP Q to the Rev-erb alpha IRES and the change in PTB cytosolic levels lead to maintenance of the oscillation profile of the Rev-erb alpha protein.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/25289
- DOI
- 10.1093/NAR/GKQ569
- ISSN
- 0305-1048
- Article Type
- Article
- Citation
- NUCLEIC ACIDS RESEARCH, vol. 38, no. 20, page. 7068 - 7078, 2010-11
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