Injectable hyaluronic acid-tyramine hydrogels for the treatment of rheumatoid arthritis
SCIE
SCOPUS
- Title
- Injectable hyaluronic acid-tyramine hydrogels for the treatment of rheumatoid arthritis
- Authors
- Kim, KS; Park, SJ; Yang, JA; Jeon, JH; Bhang, SH; Kim, BS; Hahn, SK
- Date Issued
- 2011-02
- Publisher
- ELSEVIER SCI LTD
- Abstract
- Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by inflammation of the synovial membrane, leading in turn to articular cartilage destruction. In this work, injectable tyramine modified hyaluronic acid (HA-Tyr) hydrogels were developed for the treatment of RA. HA-Tyr conjugate was synthesized by amide bond formation between carboxyl groups of HA and amine groups of tyramine. Then, HA-Tyr hydrogels were prepared by radical crosslinking reaction using H2O2 and horse-radish peroxidase. Intra-articular injection of HA-Tyr hydrogels encapsulating dexamethasone (DMT) as a model drug resulted in successful treatment of RA with reduced interlukine-6, prostaglandin E2 and four types of cytokine levels in collagen-induced arthritis animal models. Histological analysis with hematoxylin and eosin (H&E) staining also confirmed the therapeutic effect of injectable HA-Tyr hydrogels with DMT. Taken together, the injectable HA-Tyr hydrogels were thought suitable to be developed as a therapeutically effective drug carrier for the treatment of RA. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
- Keywords
- Hyaluronic acid; Hydrogel; Dexamethasone; Drug delivery; Rheumatoid arthritis; PROSTAGLANDIN-E SYNTHASE; INTRAARTICULAR INJECTION; TISSUE AUGMENTATION; CELL; THERAPY; OSTEOARTHRITIS; PROLIFERATION; INFLAMMATION; DESTRUCTION; DEGRADATION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/25039
- DOI
- 10.1016/J.ACTBIO.2010.09.030
- ISSN
- 1742-7061
- Article Type
- Article
- Citation
- ACTA BIOMATERIALIA, vol. 7, no. 2, page. 666 - 674, 2011-02
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- There are no files associated with this item.
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