The synthetic peptide Trp-Lys-Tyr-Met-Val-(D)-Met as a novel adjuvant for DNA vaccine
SCIE
SCOPUS
- Title
- The synthetic peptide Trp-Lys-Tyr-Met-Val-(D)-Met as a novel adjuvant for DNA vaccine
- Authors
- Lee, CG; Choi, SY; Park, SH; Park, KS; Ryu, SH; Sung, YC
- Date Issued
- 2005-09-07
- Publisher
- ELSEVIER SCI LTD
- Abstract
- Trp-Lys-Tyr-Met-Val-(D)-Met (WKYMVm) is a synthetic peptide known to activate human neutrophils, monocytes and dendritic cells, resulting in the enhancement of superoxide generation, bactericidal activity, chemotactic migration and survival. In this study, we demonstrated that WKYMVm enhanced the surface expression of CD80, but not that of CD40, CD86 and MHC class 11, on mouse bone marrow-derived dendritic cells which is one of the essential costimulatory signals for the induction of immune responses. Furthermore, when WKYMVm was codelivered with HIV, HBV and Influenza DNA vaccines, WKYMVm selectively enhanced the vaccine-induced CD8(+) T cell responses in a dose-dependent manner, in terms of IFN-gamma secretion and cytolytic activity. Our results indicate that a synthetic peptide, WKYMVm can function as a novel adjuvant for DNA vaccine. (c) 2005 Elsevier Ltd. All rights reserved.
- Keywords
- WKYMVm; DNA vaccine; CD80; VAL-D-MET; T-LYMPHOCYTE RESPONSES; HUMAN DENDRITIC CELLS; IMMUNE-RESPONSES; SUPEROXIDE GENERATION; PLASMID DNA; IN-VIVO; KAPPA-B; PHOSPHOINOSITIDE HYDROLYSIS; GENETIC IMMUNIZATION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/24427
- DOI
- 10.1016/j.vaccine.2005.03.051
- ISSN
- 0264-410X
- Article Type
- Article
- Citation
- VACCINE, vol. 23, no. 38, page. 4703 - 4710, 2005-09-07
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- There are no files associated with this item.
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