A small compound that inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 upregulation
SCIE
SCOPUS
- Title
- A small compound that inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 upregulation
- Authors
- Lee, HY; Park, KS; Kim, MK; Lee, T; Ryu, SH; Woo, KJ; Kwon, TK; Bae, YS
- Date Issued
- 2005-10-21
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Abstract
- Matrix metalloproteinase-9 (MMP-9) is critically involved in the tumor invasion and metastasis processes. Since TNF-alpha plays a crucial role in the regulation of MMP-9 expression, the development of molecules capable of modulating TNF-alpha-induced signaling is an issue of concern. We identified a novel synthetic compound that inhibits TNF-alpha-induced MMP-9 upregulation in the HT1080 human fibrosarcoma, cell line. The active compound SM-7368 inhibited TNF-alpha-induced MMP-9 upregulation in a concentration-dependent manner and showed maximal activity at 10 mu M. SM-7368 inhibited TNF-alpha-induced MMP-9 mRNA transcript accumulation and protein expression. We also found that SM-7368 strongly inhibits TNIF-alpha-induced NF-kappa B activity but not AP-1 activity. Moreover, we found that SM-7368 strongly inhibits the TNF-alpha-induced invasion of HT1080 human fibrosarcoma cell line. Taken together, our results demonstrate that SM-7368 is a synthetic compound that inhibits TNIF-a-induced MMP-9 expression, and thus SM-7368 should be useful for the development of chemotherapies targeting TNF-alpha-mediated,tumor invasion and metastasis. (c) 2005 Elsevier Inc. All rights reserved.
- Keywords
- matrix metalloproteinase-9; TNF-alpha; small compound; NF-kappa B; invasion; MATRIX METALLOPROTEINASES; IV COLLAGENASE; GENE-EXPRESSION; KAPPA-B; CELLS; CANCER; MICE; PATHWAY; IDENTIFICATION; METASTASIS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/24379
- DOI
- 10.1016/j.bbrc.2005.08.154
- ISSN
- 0006-291X
- Article Type
- Article
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 336, no. 2, page. 716 - 722, 2005-10-21
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