Synthesis of 2-C-hydroxymethylribofuranosylpurines as potent anti-hepatitis C virus (HCV) agents
SCIE
SCOPUS
- Title
- Synthesis of 2-C-hydroxymethylribofuranosylpurines as potent anti-hepatitis C virus (HCV) agents
- Authors
- Yoo, BN; Kim, HO; Moon, HR; Seol, SK; Jang, SK; Lee, KM; Jeong, LS
- Date Issued
- 2006-08-15
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- On the basis of potent anti-HCV activity of 2'-C-methyladenosine, novel 2'-C-hydroxymethyladenosine analogues 2a-c were synthesized from D-ribose in order to lead to favorable interaction with HCV polymerase. Among compounds tested, adenosine derivative 2a exhibited potent anti-HCV activity, indicating that the hydroxyl group of 2'-C-hydroxymethyl substituent led to favorable interaction with HCV polymerase. (c) 2006 Elsevier Ltd. All rights reserved.
- Keywords
- hepatitis C virus; RNA dependent RNA polymerase; 2 ' -C-hydroxymethyladenosine; anti-HCV agent; DEPENDENT RNA-POLYMERASE; VIRAL-HEPATITIS; GENOME
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/23901
- DOI
- 10.1016/j.bmcl.2006.05.089
- ISSN
- 0960-894X
- Article Type
- Article
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 16, page. 4190 - 4194, 2006-08-15
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