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Cited 45 time in webofscience Cited 47 time in scopus
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Neuralized-2 regulates a Notch ligand in cooperation with mind bomb-1 SCIE SCOPUS

Title
Neuralized-2 regulates a Notch ligand in cooperation with mind bomb-1
Authors
Song, RKoo, BKYoon, KJYoon, MJYoo, KWKim, HTOh, HJKim, YYHan, JKKim, CHKong, YY
Date Issued
2006-11-24
Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLO
Abstract
Mutations in Drosophila neuralized (Dneur) result in a variety of developmental defects that closely resemble those of Notch mutants and other Notch pathway mutants. However, mice with disrupted neur1 do not show any aberrant cell fate specifications in neurogenesis and somitogenesis. Thus, we speculated that other vertebrate neur homolog(s) might compensate for loss of the neur gene. Here, we report the paralog of mouse Neur1, named Neuralized-2 (Neur2), which is a ubiquitin-protein isopeptide ligase (E3) that interacts with and ubiquitinates Delta. Both murine Neur1 and Neur2 have similar degrees of homology to DNeur, and neur2 is expressed in patterns similar to those of neur1 in embryos, suggesting potential functional redundancy. Interestingly, two distinct classes of E3 ligases, Mind bomb-1 (Mib1) and Neur2, have cooperative but distinct roles in Delta endocytosis to Hrs-positive vesicles, i.e. Mib1 functions in the initial step of Delta endocytosis, and Neur2 is required for targeting endocytosed Delta to Hrs-positive vesicles. Thus, our study provides a new insight into how distinct E3 ligases work together in the endocytic pathways for Notch signaling.
Keywords
CELL FATE; UBIQUITIN LIGASE; SIGNALING PATHWAY; DROSOPHILA DEVELOPMENT; NEUROGENIC GENES; ACTIVATE NOTCH; DELTA; ENDOCYTOSIS; EXPRESSION; ZEBRAFISH
URI
https://oasis.postech.ac.kr/handle/2014.oak/23721
DOI
10.1074/jbc.M606601200
ISSN
0021-9258
Article Type
Article
Citation
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, no. 47, page. 36391 - 36400, 2006-11-24
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한진관HAN, JIN KWAN
Dept of Life Sciences
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