Intranasal immunization with influenza virus and Korean mistletoe lectin C (KML-C) induces heterosubtypic immunity in mice
SCIE
SCOPUS
- Title
- Intranasal immunization with influenza virus and Korean mistletoe lectin C (KML-C) induces heterosubtypic immunity in mice
- Authors
- Song, SK; Moldoveanu, Z; Nguyen, HH; Kim, EH; Choi, KY; Kim, JBA; Mestecky, J
- Date Issued
- 2007-08-21
- Publisher
- ELSEVIER SCI LTD
- Abstract
- The mucosal adjuvanticity of Korean mistletoe lectin C (KML-Q was investigated in mice intranasally immunized with inactivated influenza virus (H IN1). Mucosal and systemic immune responses were compared to those induced with cholera toxin B subunit (CTB). KML-C increased influenza-specific antibodies with dominant IgG1 subclass in serum, IgG in genital secretions and IgA in saliva, and significantly enhanced in fl uenza- specific lymphocyte proliferation and cytotoxic activity in spleens and in mediastinal lymph nodes. When KML-C was used as a mucosal adjuvant, mice were completely protected from mortality after the challenge with a homologous (HINI) mouse-adapted influenza virus. After challenge with heterologous (H3N2) influenza virus the level of heterosubtypic immunity in KML-C-treated mice was comparable to that of mice that received CTB as adjuvant. These findings suggest that KML-C may be used as an effective mucosal adjuvant. (c) 2007 Elsevier Ltd. All rights reserved.
- Keywords
- Korean mistletoe lectin; mucosal adjuvant; influenza virus; heterosubtypic immunity; VISCUM-ALBUM-COLORATUM; CYTOTOXIC T-LYMPHOCYTES; ADJUVANT ACTIVITY; PLANT-LECTINS; TUMOR-CELLS; INFECTION; RESPONSES; METASTASIS; EXTRACT; ENHANCE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/23211
- DOI
- 10.1016/J.VACCINE.20
- ISSN
- 0264-410X
- Article Type
- Article
- Citation
- VACCINE, vol. 25, no. 34, page. 6359 - 6366, 2007-08-21
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