Highly enantioselective dynamic kinetic resolution of 1,2-diarylethanols by a lipase-ruthenium couple
SCIE
SCOPUS
- Title
- Highly enantioselective dynamic kinetic resolution of 1,2-diarylethanols by a lipase-ruthenium couple
- Authors
- Kim, MJ; Choi, YK; Kim, S; Kim, D; Han, K; Ko, SB; Park, J
- Date Issued
- 2008-03-20
- Publisher
- AMER CHEMICAL SOC
- Abstract
- A practical procedure has been developed for the dynamic kinetic resolution of 1,2-diarylethanols. This procedure employs a highly enantioselective lipase from Pseudomonas stutzeri (trade name, lipase TL) as the resolution catalyst and a ruthenium complex as the racemization catalyst. Sixteen 1,2-diarylethanols have been efficiently resolved to provide their acetyl derivatives with good yields (95-97%) and high enantiomeric excesses (96-99%).
- Keywords
- METAL COMBO CATALYSIS; SECONDARY ALCOHOLS; RACEMIZATION CATALYSTS; AMBIENT-TEMPERATURE; ASYMMETRIC TRANSFORMATIONS; ENZYMATIC RESOLUTION; ALLYLIC ALCOHOLS; ENANTIOMERS; ENZYMES; COMBINATION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/22867
- DOI
- 10.1021/OL800163Z
- ISSN
- 1523-7060
- Article Type
- Article
- Citation
- ORGANIC LETTERS, vol. 10, no. 6, page. 1295 - 1298, 2008-03-20
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- There are no files associated with this item.
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