Murine thymic stromal lymphopoietin promotes the differentiation of regulatory T cells from thymic CD4(+)CD8(-)CD25(-) naive cells in a dendritic cell-independent manner
SCIE
SCOPUS
- Title
- Murine thymic stromal lymphopoietin promotes the differentiation of regulatory T cells from thymic CD4(+)CD8(-)CD25(-) naive cells in a dendritic cell-independent manner
- Authors
- Lee, JY; Lim, YM; Park, MJ; Min, SY; Cho, ML; Sung, YC; Park, SH; Kim, HY; Cho, YG
- Date Issued
- 2008-02
- Publisher
- NATURE PUBLISHING GROUP
- Abstract
- Human thymic stromal lymphopoietin (TSLP) activates dendritic cells (DCs), which promote the proliferation and differentiation of CD4(+) T cells. However, murine TSLP (mTSLP) can act directly on CD4(+) T cells and bring about their differentiation. We studied the role of mTSLP in the generation of CD4(+)CD25(+)FoxP3(+) T cells from thymocytes. mTSLP promoted the differentiation of CD4(+) single-positive thymocytes into CD4(+)CD25(+)FoxP3(+) T cells. Although we cannot exclude an effect of TSLP mediated through DCs due to co- stimulatory effects, mTSLP appears to act directly on thymocytes. T- cell receptor and TSLP receptor signaling act synergistically on thymocytes to generate CD4(+)CD25(+) FoxP3(+) T cells. mTSLP may play an important role in maintaining immune tolerance by promoting the conversion of thymocytes into natural regulatory T cells via escape from negative selection.
- Keywords
- TSLP; DCs; Treg; negative selection; TCR; MEDIATED SIGNAL-TRANSDUCTION; HUMAN EPITHELIAL-CELLS; ALLERGIC INFLAMMATION; SUPPRESSOR COMMITMENT; IN-VIVO; TSLP; INDUCE; INSTRUCTION; HOMEOSTASIS; TOLERANCE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/22861
- DOI
- 10.1038/sj.icb.7100127
- ISSN
- 0818-9641
- Article Type
- Article
- Citation
- IMMUNOLOGY AND CELL BIOLOGY, vol. 86, no. 2, page. 206 - 213, 2008-02
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