Asymmetric reductive acylation of aromatic ketoximes by enzyme-metal cocatalysis
SCIE
SCOPUS
- Title
- Asymmetric reductive acylation of aromatic ketoximes by enzyme-metal cocatalysis
- Authors
- Han, K; Park, J; Kim, MJ
- Date Issued
- 2008-06-06
- Publisher
- AMER CHEMICAL SOC
- Abstract
- We have developed an efficient procedure for the asymmetric synthesis of chiral amides from ketoximes. This one-pot procedure employs two different types of catalysts, Pd nanocatalyst and lipase, for three consecutive transformations including hydrogenation, racemization, and acylation. Eight ketoximes have been efficiently transformed to the corresponding amides in good yields (83-92%) and high enantiomeric excesses (93-98%).
- Keywords
- DYNAMIC KINETIC RESOLUTION; PRIMARY AMINES; CATALYST; AMINATION; PALLADIUM; LIPASE; PD; TRANSFORMATIONS; RACEMIZATION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/22734
- DOI
- 10.1021/JO800270N
- ISSN
- 0022-3263
- Article Type
- Article
- Citation
- JOURNAL OF ORGANIC CHEMISTRY, vol. 73, no. 11, page. 4302 - 4304, 2008-06-06
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