Article
Cited 35 time in 
Cited 37 time in 
Cited 37 time in
Metadata Downloads
Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligand SCIE SCOPUS
- Title
- Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligand
- Authors
- Park, JJ; Lee, JH; Ghosh, SC; Bricard, G; Venkataswamy, MM; Porcelli, SA; Chung, SK
- Date Issued
- 2008-07-15
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- KRN7000 is an important ligand identified for CD1d protein of APC, and KRN7000/CD1d complex can stimulate NKT cells to release Th1 and Th2 cytokines. In an effort to understand the structure-activity relationships, we have carried out the synthesis of a complete set of the eight KRN7000 stereoisomers, and their biological activities have been examined. Crown copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.
- Keywords
- alpha-GalCer; KRN7000 stereoisomers; phytosphingosine; NKT cell; IMMUNOMODULATORY ALPHA-GALACTOGLYCOSPHINGOLIPIDS; T-CELLS; STIMULATING PROPERTIES; GALACTOSYLCERAMIDE; GLYCOLIPIDS; ACTIVATION; RECEPTOR; ANALOGS; PHYTOSPHINGOSINE; RECOGNITION
- ISSN
- 0960-894X
- Article Type
- Article
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 14, page. 3906 - 3909, 2008-07-15
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.