Open Access System for Information Sharing

Login Library

 

Article
Cited 25 time in webofscience Cited 25 time in scopus
Metadata Downloads

Novel Guanidine-Containing Molecular Transporters Based on Lactose Scaffolds: Lipophilicity Effect on the Intracellular Organellar Selectivity SCIE SCOPUS

Title
Novel Guanidine-Containing Molecular Transporters Based on Lactose Scaffolds: Lipophilicity Effect on the Intracellular Organellar Selectivity
Authors
Biswas, GJeon, OYLee, WSKim, DCKim, KTLee, SChang, SChung, SK
Date Issued
2008-01
Publisher
WILEY-V C H VERLAG GMBH
Abstract
We have synthesized two lactose-based molecular transporters, each containing seven guanidine residues attached to the lactose scaffold through omega-aminocarboxylate linker chains of two different lengths, and have examined their cellular uptakes and intracellular and organellar localizations in HeLa cells, as well as their tissue distributions in mice. Both molecular transporters showed higher cellular uptake efficiencies than Arg8, and wide tissue distributions including the brain. Mitochondrial localization is of special interest because of its potential relevance to "mitochondrial diseases". Interestingly, it has been found that the intracellular localization sites of the G7 molecular transporters-namely either mitochondria or lysosomes and endocytic vesicles-are largely determined by the linker chain lengths, or their associated lipophilicities.
Keywords
blood-brain barrier; drug delivery; lipophilicity; organelle selectivity; tissue selectivity; ARGININE-RICH PEPTIDES; MEMBRANE-PERMEABLE PEPTIDES; CELLULAR UPTAKE; DRUG-DELIVERY; MITOCHONDRIA; DESIGN; TRANSLOCATION; DISEASE; MACROPINOCYTOSIS; REARRANGEMENT
URI
https://oasis.postech.ac.kr/handle/2014.oak/22411
DOI
10.1002/chem.200801160
ISSN
0947-6539
Article Type
Article
Citation
CHEMISTRY-A EUROPEAN JOURNAL, vol. 14, no. 30, page. 9161 - 9168, 2008-01
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

김경태KIM, KYONG TAI
Dept of Life Sciences
Read more

Views & Downloads

Browse