REDUCED EXPRESSION OF PLC-GAMMA DURING THE DIFFERENTIATION OF MOUSE F9 TERATOCARCINOMA CELLS
SCIE
SCOPUS
- Title
- REDUCED EXPRESSION OF PLC-GAMMA DURING THE DIFFERENTIATION OF MOUSE F9 TERATOCARCINOMA CELLS
- Authors
- KIM, KW; LEE, HY; LEE, YH; RYU, SH; SUH, PG
- Date Issued
- 1993-02
- Publisher
- ELSEVIER SCI IRELAND LTD
- Abstract
- Expression of phosphoinositide-specific phospholipase C (PLC)-gamma during the retinoic acid(RA)-induced differentiation of F9 teratocarcinoma stem cells was investigated. PLC-gamma activity and PLC-gamma protein content were decreased during the differentiation of F9 teratocarcinoma stem cells induced by a combination (RACt) of RA, dibutyryl cyclic AMP (C) and theophylline (T). However, PLC-gamma activity and protein levels in RA- or C- and T-treated F9 cells remained the same as that of the F9 stem cells. Northern analysis of the 5.4-kb PLC-gamma transcript in differentiated F9 cells by RACT revealed that RACT decreased the PLC-gamma gene expression. These results suggest that the expression of PLC-gamma is negatively controlled by RACT treatment in the differentiation of F9 teratocarcinoma stem cells.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/22110
- DOI
- 10.1016/0304-3835(93)90152-Y
- ISSN
- 0304-3835
- Article Type
- Article
- Citation
- CANCER LETTERS, vol. 68, no. 2-3, page. 237 - 242, 1993-02
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