ELEVATED CONTENT OF PHOSPHOLIPASE C-GAMMA-1 IN COLORECTAL-CANCER TISSUES
SCIE
SCOPUS
- Title
- ELEVATED CONTENT OF PHOSPHOLIPASE C-GAMMA-1 IN COLORECTAL-CANCER TISSUES
- Authors
- KIM, SS; KIM, YI; LEE, YH; NOH, DY; PARK, JG; RYU, SH; SUH, PG
- Date Issued
- 1994-01-01
- Publisher
- Nihon Kokakurui Gakkai
- Abstract
- Background. Phospholipase C isozymes (PLC) play a role in ligand-mediated signal transduction for cellular activity, such as proliferation and differentiation. However, the biologic significance of their molecules in carcinogenesis or tumor progression is yet to be determined. Methods. Using PLC isozyme-specific antibodies, the relative content of PLC in human colorectal carcinomas and in normal colonic mucosa was examined. Results. Immunoreactive analysis revealed considerably higher levels of PLC-gamma 1 protein in 15 of 17 colorectal carcinomas and little difference in PLC-beta 1 or PLC-delta 1 content compared with normal colorectal tissues. By radioimmunoassay and Western blotting, PLC-gamma 1 showed threefold to fourfold more expression in carcinomas than that in normal tissues. Conclusion. Although factors that might influence the level of PLC-gamma 1 expression in colorectal carcinomas still remain obscure, the fact that most colorectal carcinomas display elevated levels of PLC-gamma 1 expression implies that PLC-gamma 1 may play an important role in proliferation of colorectal carcinoma cells.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/22000
- DOI
- 10.1002/1097-0142(19940101)73:1<36::AID-CNCR2820730108>3.0.CO;2-5
- ISSN
- 0918-1989
- Article Type
- Article
- Citation
- CANCER, vol. 73, no. 1, page. 36 - 41, 1994-01-01
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.