The efficient resolution of protected diols and hydroxy aldehydes by lipases: Steric auxiliary approach and synthetic applications.

Abstract

1,n-Diols (n = 2 - 5) and 2-hydroxy aldehydes protected with a steric auxiliary are transformed by Pseudomonas lipases with high enantioselectivity, thus allowing the efficient resolution of these molecules and the synthesis of related derivatives with high optical purity.