p-Quinone methides as geometric analogues of quinolone carboxylate antibacterials
SCIE
SCOPUS
- Title
- p-Quinone methides as geometric analogues of quinolone carboxylate antibacterials
- Authors
- Chung, SK; Lee, JW; Shim, NY; Kwon, TW
- Date Issued
- 1996-06-18
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- In an attempt to examine the role of the N(I)-alkyl or -aryl moiety of the quinolone antibacterials, several quinone methides such as perinaphthindenone carboxylates (6) were synthesized as 1-carba(sp(2)) analogues of the quinolone structure, and found to have no antibacterial activity. These results together with literature information are interpreted as the necessity of a: least one nitrogen atom at the position of 1, 3, 4a, 6 or 8 in the quinolone-like skeleton for the antibacterial activities. Copyright (C) 1996 Elsevier Science Ltd
- Keywords
- DNA-GYRASE INHIBITORS; POLYPHOSPHORIC ACID; OXOLINIC ACID; MECHANISM; CYCLIZATION; BINDING; INDOLES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/21550
- DOI
- 10.1016/0960-894X(96)00218-1
- ISSN
- 0960-894X
- Article Type
- Article
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 12, page. 1309 - 1312, 1996-06-18
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- There are no files associated with this item.
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