A diastereoselective phenylselenium-induced lactamization of olefinic amides. A possible route to alpha- and beta-amino acid derivatives

Abstract

The organoselenium-induced cyclofunctionalization of (S)-N-(alpha,beta-unsaturated-acyl)prolinamides was found to produce with a high degree of chirality transfer, 7- and 6-membered bislactam derivatives depending on the substitution pattern of the starting material. (C) 1997 Published by Elsevier Science Ltd.