Chiral 2,2-disubstituted cyclopropanecarboxylic acids: Effective derivatizing agents for analysis of enantiomeric purity of alcohols and for resolution of 1,1'-bi-2-naphthol
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SCOPUS
- Title
- Chiral 2,2-disubstituted cyclopropanecarboxylic acids: Effective derivatizing agents for analysis of enantiomeric purity of alcohols and for resolution of 1,1'-bi-2-naphthol
- Authors
- Kim, HC; Choi, S; Kim, H; Ahn, KH; Koh, JH; Park, J
- Date Issued
- 1997-06-02
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- The enantiomeric purities of secondary alcohols can be easily analyzed by GC and HPLC through derivatization to the esters of 2,2-disubstituted cyclopropanecarboxylic acids 1, and by H-1 NMR analysis of the esters of 2,2-diphenylcyclopropanecarboxylic acid (Ib). In addition racemic 1,1'-bi-2-naphthol is easily resolved through derivatization to monoesters of 2,2-dimethy]cyclopropanecarboxylic acid (1a), which are crystallized selectively and sequentially in high yields with high optical purities. (C) 1997 Elsevier Science Ltd.
- Keywords
- CHEMICAL-SHIFTS; EFFICIENT; REAGENTS; H-1-NMR
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/21301
- DOI
- 10.1016/S0040-4039(97)00789-2
- ISSN
- 0040-4039
- Article Type
- Article
- Citation
- TETRAHEDRON LETTERS, vol. 38, no. 22, page. 3959 - 3962, 1997-06-02
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- There are no files associated with this item.
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