Overexpression of phospholipase C-gamma 1 in rat 3Y1 fibroblast cells leads to malignant transformation
SCIE
SCOPUS
- Title
- Overexpression of phospholipase C-gamma 1 in rat 3Y1 fibroblast cells leads to malignant transformation
- Authors
- Chang, JS; Noh, DY; Park, IA; Kim, MJ; Song, H; Ryu, SH; Suh, PG
- Date Issued
- 1997-12-15
- Publisher
- AMER ASSOC CANCER RESEARCH
- Abstract
- Phospholipase C-gamma 1 (PLC-gamma l) mediates signals from various extracellular origins to evoke cellular events such as mitogenesis. Previously, we reported that PLC-gamma 1 was highly expressed in colorectal cancer and familial adenomatous polyposis, suggesting that PLC-gamma 1 might be oncogenic. In this study, we have established rat 3Y1 fibroblasts that overexpress whole PLC-gamma 1 and src homology 2 (SH2)-SH2-SH3 domain of PLC-gamma 1. These cells showed a transformed phenotype and were tumorigenic when transplanted into nude mice. These results indicate that overexpression of PLC-gamma 1 could transform rat fibroblasts, and the transformation is mediated by SH2-SH2-SH3 domain of PLC-gamma 1.
- Keywords
- ELEVATED CONTENT; DNA-SYNTHESIS; CARCINOMAS; ANTIBODIES; DOMAIN; SRC
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/20936
- ISSN
- 0008-5472
- Article Type
- Article
- Citation
- CANCER RESEARCH, vol. 57, no. 24, page. 5465 - 5468, 1997-12-15
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- There are no files associated with this item.
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