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Synthesis of hexapeptide and tetrapeptide analogues of the immunomodulating peptides SCIE SCOPUS
- Title
- Synthesis of hexapeptide and tetrapeptide analogues of the immunomodulating peptides
- Date Issued
- 1998-01-21
- Publisher
- ROYAL SOC CHEMISTRY
- Abstract
- Two hexapeptide and two tetrapeptide analogues of the bioactive hexapeptides [(Trp/Met/Phe)-Lys-Tyr-(Met/Val)-(Pro/Val)-Met] have been synthesized by incorporating novel peptide isosteres such as 2-isoxazoline, (E)-alkene, and reduced amide isosteres, These immunomodulating hexapeptides are known to stimulate the formation of inositol phosphates in lymphocyte cell lines.
- Keywords
- KETOMETHYLENE DIPEPTIDE ISOSTERES; ENZYME-INHIBITORS; ENKEPHALIN ANALOG; BOND; PEPTIDOMIMETICS; 2-ISOXAZOLINE; CHEMISTRY; REDUCTION
- ISSN
- 0300-922X
- Article Type
- Article
- Citation
- JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, no. 2, page. 359 - 365, 1998-01-21
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Related Researcher
- 류성호RYU, SUNG HO
- Dept of Life Sciences