Immuno-stimulatory effects of bacterial-derived plasmids depend on the nature of the antigen in intramuscular DNA inoculations
SCIE
SCOPUS
- Title
- Immuno-stimulatory effects of bacterial-derived plasmids depend on the nature of the antigen in intramuscular DNA inoculations
- Authors
- Lee, SW; Sung, YC
- Date Issued
- 1998-07
- Publisher
- BLACKWELL SCIENCE LTD
- Abstract
- The CpG motifs of bacterial-derived plasmids augment antigen-specific immune responses and steer those responses towards the T helper 1 (Th1) type. In this study, we have addressed the immune-stimulatory effect of intramuscular co-administration of CpG motifs containing vector DNA. on the modulation of immune responses to the haemagglutinin (HA) and the nucleoprotein (NP) proteins of influenza virus. The co-administration of Vector DNA with a HA-encoding plasmid DNA showed a significant enhancement in the total IgG response, the generation of cytotoxic T lymphocyte (CTL), and the T-cell proliferative response. In the case of NP-encoding plasmid DNA inoculations, the co-administration of vector DNA slightly decreased the total IgG response, although the IgG2a/IgG1 ratio and the CTL responses to NP were significantly increased. These observations suggest that the immune-stimulatory effects of bacterial-derived plasmids depend upon the nature of the co-administered antigen.
- Keywords
- CPG MOTIFS; VACCINES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/20716
- DOI
- 10.1046/j.1365-2567.1998.00557.x
- ISSN
- 0019-2805
- Article Type
- Article
- Citation
- IMMUNOLOGY, vol. 94, no. 3, page. 285 - 289, 1998-07
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