Enzymatic resolution of secondary alcohols coupled with ruthenium-catalyzed racemization without hydrogen mediator
SCIE
SCOPUS
- Title
- Enzymatic resolution of secondary alcohols coupled with ruthenium-catalyzed racemization without hydrogen mediator
- Authors
- Koh, JH; Jung, HM; Kim, MJ; Park, J
- Date Issued
- 1999-08-20
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- (eta(5)-Indenyl)RuCl(PPh3)(2) was found to catalyze the racemization of secondary alcohols in the presence of triethylamine and oxygen. Unlike previously reported metal-catalyzed racemizations, ketones were not required as hydrogen mediators in our process. The Ru-catalyzed racemization was coupled with enzymatic acetylation for the dynamic kinetic resolution of secondary alcohols to give chiral acetates in good yields (60-98%) with high enantioselectivities (82-99% ee). (C) 1999 Elsevier Science Ltd. All rights reserved.
- Keywords
- DYNAMIC KINETIC RESOLUTION; ORGANIC-SYNTHESIS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/20325
- DOI
- 10.1016/S0040-4039(99)01237-X
- ISSN
- 0040-4039
- Article Type
- Article
- Citation
- TETRAHEDRON LETTERS, vol. 40, no. 34, page. 6281 - 6284, 1999-08-20
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- There are no files associated with this item.
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