La protein is required for efficient translation driven by encephalomyocarditis virus internal ribosomal entry site
SCIE
SCOPUS
- Title
- La protein is required for efficient translation driven by encephalomyocarditis virus internal ribosomal entry site
- Authors
- Kim, YK; Jang, SK
- Date Issued
- 1999-12
- Publisher
- SOC GENERAL MICROBIOLOGY
- Abstract
- Translation of internal ribosomal entry site (IRES)-dependent mRNAs is mediated by RNA-binding proteins as well as canonical translation factors. In order to elucidate the roles of RNA-binding proteins in IRES-dependent translation, the role of polypyrimidine tract-binding protein (PTB) and La protein in encephalomyocarditis virus (EMCV) IRES-dependent translation was investigated. PTB was required for efficient EMCV IRES-driven translation but, intriguingly, an excess of PTB suppressed it. Such a translational suppression by surplus PTB was relieved by addition of La protein. A possible role for La protein in IRES-dependent translation is discussed.
- Keywords
- TRACT-BINDING-PROTEIN; RNA-POLYMERASE-III; MOUTH-DISEASE VIRUS; 5' NONTRANSLATED REGION; TERMINATION FACTOR LA; MESSENGER-RNA; POLIOVIRUS RNA; TRANSCRIPTION TERMINATION; INITIATION-FACTOR; CELLULAR PROTEIN
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/20188
- DOI
- 10.1099/0022-1317-80-12-3159
- ISSN
- 0022-1317
- Article Type
- Article
- Citation
- JOURNAL OF GENERAL VIROLOGY, vol. 80, no. PT 12, page. 3159 - 3166, 1999-12
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